Deletion of the PDGFR-β Gene Affects Key Fibroblast Functions Important for Wound Healing
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چکیده
منابع مشابه
Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing.
We used both a gene knockout approach and pharmacologic modulation to study the implication of the JNK pathway in regulating fibroblast motility, capacity to contract mechanically unloaded collagen gels, and type I collagen gene expression in vitro. These parameters, which are important for tissue repair, are positively regulated by transforming growth factor (TGF)-beta, a cytokine viewed as pl...
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15 صفحه اولFibroblast differentiation in wound healing and fibrosis.
The contraction of granulation tissue from skin wounds was first described in the 1960s. Later it was discovered that during tissue repair, fibroblasts undergo a change in phenotype from their normal relatively quiescent state in which they are involved in slow turnover of the extracellular matrix, to a proliferative and contractile phenotype termed myofibroblasts. These cells show some of the ...
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Sue Porter is Sister, Plastic Surgery Dressing Clinic, Queen Victoria NHS Foundation Trust, East Grinstead, West Sussex Although wound contraction appears to be organised by fibroblast cells within granulation tissue, the interaction between fibroblasts and the extracellular matrix is not fully understood. There are two dichotomous theories: the cell contraction theory and the fibroblast (cell ...
متن کاملOcular fibroblast diversity: implications for inflammation and ocular wound healing.
PURPOSE Various ocular and orbital tissues differ in their manifestations of inflammation, although the reasons for this are unclear. Such differences may be due to behaviors exhibited by resident cell types, including fibroblasts. Fibroblasts mediate immune function and produce inflammatory mediators. Chronic stimulation of ocular fibroblasts can lead to prolonged inflammation and, in turn, to...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m413081200